RSA consultant Kim Travis has contributed to a recent publication which looks to identify a NAMs-based classification system capable of categorising chemicals based on their bioactivity and bioavailability. The classification system, developed for human systemic toxicity, focused on repeated dose toxicity. The proposed framework integrated three lines of evidence – in silico predictions, in vitro bioavailability and PBK modelling, and in vitro bioactivity assays. Assessing twelve chemicals through the proposed framework, the authors demonstrate that the matrix suggested by the EPAA’s ‘NAM Designathon 2023’, in which chemicals would be categorised into three levels of concern (low, medium and high), could be used. However, some further work is required to explore the range of assays used, the framework categorisation being defined, and how to fit such a matrix into a tiered approach.
Read the publication here.
Kim Travis is a Consultant specialising in Toxicology and Environmental Sciences. Kim has extensive experience in developing an understanding of the fate and effects of small molecules in biological systems. His expertise is in understanding and modelling the mammalian kinetics of small molecules, including study design and interpretation, and the relationship to biological effects (desired or otherwise). He has also worked on new molecule discovery projects. Kim has published and presented extensively, and worked on many panels and committees as a recognised expert.