RSA are delighted to share a link below to a collaborative publication in “Toxicology and Applied Pharmacology” describing the mode of action of the pesticide active substance Valifenalate inducing mild thyroid effects in rats and dogs in vivo. Comparative in vitro assays in rat, dog and human hepatocytes showed marked species differences in the induction of liver enzymes, T4-UGT activity and T4 disappearance.
These results, alongside assays negative for inhibition of TPO, DIO and NIS activities, demonstrate that the mild thyroid effects observed for Valifenalate in rats and dogs in vivo occur via an indirect liver enzyme mediated mode of action that is irrelevant to humans. This is another example amongst the majority of pesticides with thyroid effects that do not act directly on the thyroid but indirectly via liver enzyme induction.
You can read the full publication here.